Cancer digital twins

Oncology digital twins to support drug development decision-making.

License protocol-aligned oncology cohorts, explore outcomes in the Evinexus evidence platform, and apply the evidence to trial design and comparator strategies.

Protocol-aligned cohorts Regulatory-grade delivery Clinician-led validation

Protocol-aligned cohort

Advanced solid tumor · 2L+

412eligible patients
Median age 5354% female
Illustrative

Award-winning evidence

Global Scrip Award (2018) — Best Use of Real-World Evidence

21 / 21

Estimate agreement with published trial results

30–50%

Fewer control patients (external-control simulations)

~3.1 yrs

Follow-up removed in the emulation

What is a digital twin?

A patient-level representation aligned to a defined study question.

Evinexus combines harmonized oncology data, physician-led curation, and validation to produce patient-level cohorts aligned to your protocol and evidence question.

Each cohort includes defined endpoints, documented provenance, and a stated intended use.

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Foundation

Oncology data

Longitudinal clinical variables, treatment, and outcomes.

Evinexus

Twin cohort

Curated, validated, protocol-aligned patients.

Application

Decision evidence

Control arms, trial design, and development strategy.

Population fitEndpoint qualityFollow-upTraceabilityIntended use

What Evinexus delivers

Digital twin data and a platform to use it.

With Evinexus, sponsors can minimize the coordination needed across separate data sources to answer your research question.

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Digital Twin Data

Patient-level oncology cohorts scoped to the indication, eligibility criteria, endpoints, follow-up, and intended study question.

Rare and orphan oncology focusLongitudinal endpointsStandardized analysis-ready delivery
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Evidence Platform

A workspace for examining cohort characteristics, comparing outcomes, and reviewing scenario assumptions.

Cohort explorationOutcome analysisSponsor-ready interpretation
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Evinexus scientists support feasibility, study design, analysis, and interpretation.

Applications

Apply digital twins across trial design and evidence generation.

External control arms

Build a protocol-aligned comparator when a concurrent control is infeasible or impractical.

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Hybrid control arms

Supplement a smaller randomized control with prespecified external evidence.

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Trial and program decisions

Assess feasibility, population assumptions, endpoints, and development scenarios before committing the study design.

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Validation

Tested against published Phase 3 trial results.

Evinexus has evaluated whether digital twin cohorts reproduce published treatment and control estimates in landmark Phase 3 trials. Review the endpoint-level comparisons, regulatory context, and limitations on the Evidence page.

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Assess whether digital twins fit your study.

Share the indication, population, endpoint, and intended use. Evinexus will review whether the available data can support the question.