Cancer digital twins

Protocol-aligned oncology digital twin cohorts, ready for analysis.

For clinical development, biostatistics and real-world evidence teams: license digital twin data, explore it in the evidence platform, with scientific support scoped to your study question.

Protocol-aligned cohorts Analysis-ready delivery Clinician-led validation

Protocol-aligned cohort

Advanced solid tumor · 2L+

412eligible patients

Median age 5354% female

Illustrative

Illustrative platform demonstration using simulated data; not a validation result.

What is a digital twin?

A patient-level representation aligned to a defined study question.

An Evinexus digital twin is a modeled patient or cohort representation derived from real-world data. Cohorts are aligned to a defined oncology research question, population and intended use.

The licensed deliverable is a protocol-aligned cohort with defined endpoints and supporting provenance and quality documentation. Review the cohort’s scope and evidence before applying it to a study.

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Foundation

Oncology data

Longitudinal clinical variables, treatment, and outcomes.

Evinexus

Twin cohort

RWD-derived patient representations aligned to the study question.

Application

Decision evidence

Control arms, trial design, and development strategy.

Population fitEndpoint qualityFollow-upTraceabilityIntended use

What Evinexus delivers

Digital twin data and a platform to use it.

License a cohort for a defined study question and use the evidence platform to examine its characteristics, outcomes and assumptions. Scientific support connects the data to the analysis.

Digital Twin Data

Patient-level oncology cohorts scoped to the indication, eligibility criteria, endpoints, follow-up, and intended study question.

Rare and orphan oncology focusLongitudinal endpointsStandardized analysis-ready delivery

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Evidence Platform

A workspace for examining cohort characteristics, comparing outcomes, and reviewing scenario assumptions.

Cohort explorationOutcome analysisSponsor-ready interpretation

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Evinexus scientists support feasibility, study design, analysis, and interpretation.

Applications

Apply digital twins across trial design and evidence generation.

External control arms

Earlier patients provide an external control for a single-arm trial.

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Hybrid control arms

Digital twin controls supplement the randomized control arm so it can be smaller.

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Subgroup targeting

Digital twin cohorts show where the effect concentrates, by biomarker, line of therapy or regimen, so eligibility can be sharpened.

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Platform and adaptive trials

Several arms share one control as they enter and leave, with digital twin controls augmenting the randomized one.

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Retrospective study · CheckMate-057

A published trial provides the benchmark.

CheckMate-057 reproduced with an Evinexus digital twin control, 194 days sooner to the primary analysis.

Results are retrospective and study-specific. Prospective and regulatory validation remains required.

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Assess whether digital twins fit your study.

Share the indication, population, endpoint, and intended use. Evinexus will review whether the available data can support the question.